In the middle of a New Year's Eve blizzard, the staff and patients of Angels of Mercy Hospital are held hostage by armed gunmen. Their target is Dr. Gina Freeman, who is holding vigil over her wounded fiancé, Detective Jerry Boyle. Stranded outside the hospital is ER physician Linda Fiore, whose past holds the secret the hitmen are willing to kill for. With the cold-blooded killers in control, no one may live to see the New Year.

CJ Lyons returns to the front lines of the ER and the lives and loves of four very special women. Angels of Mercy Hospital charge nurse Nora Halloran has been living with a painful secret for two long years. When a coworker is assaulted and killed, Nora must face her deepest fears and reveal all her secrets to the man she loves to stop the killer from striking again.

A gripping behind-the-scenes drama of four women who face life and death every day

On her first day at Pittsburgh's Angels of Mercy Medical Center, L.A.-transplant Lydia Fiore, the new ER attending physician, loses a patient: the Chief of Surgery's son. Now, to save her career, Lydia must discover the truth behind her patient's death, even as it leads her into unfamiliar-and risky-territory.

At least she's not alone. There's med student Amanda, a sweet Southern belle with problems of her own; Gina, a resident with a chip on her shoulder; and Nora, the no-nonsense charge nurse with a cool head but a fiery temper. Not to mention the paramedic who'd like to try out his bedside manner on Lydia.

On rotation at Pittsburgh's Angels of Mercy Hospital and struggling to finish medical school, Amanda Mason-with the help of her friends-must solve a medical mystery before she becomes the next victim.