Sassy Melanie Marr is a phlebotomist who has terminal leukemia.The good news is that her doctor, dark and handsome Jakob Farkas, has a radical cure. As a vampire, he has the ability to heal her. But there's one small hitch, tired of his lonely existence, Farkas has not fed in over 100 years and needs to be brought back to health before he can help Melanie, with whom he has fallen in love.

Although Melanie doesn't believe the crazy doctor's story, she doesn't have much else going on at the moment besides dying. So she leaves boring Scranton and her tedious job in order to join Farkas as he travels around the world in search of a mystical cure.

As they await the arrival of the Spring Equinox in the legendary caves in Lascaux, France, Melanie wonders if she can overcome the greatest obstacle to her cure: her very mortality.

When Sorelle’s Saturday shopping is interrupted by Witman, an artist who claims he just has to capture her wonderful bone structure, she thinks she’s heard better pickup lines. She agrees to pose for him because her horoscope told her she would have an adventurous day, and who is she to pass up an afternoon romp? But the handsome bohemian really does want her to pose for him! As the painting session goes on and Witman's sensuous brushstrokes push her over the edge, a desperate Sorelle must eventually take matters into her own hands.