Emergency room nurse, Roxanne Carter is a loser-magnet wishing she could enjoy her single life. Commiserating with girlfriends over butterscotch martinis creates the idea of The Dating Manifesto—a not so scientific research project which promises to point the way to dating success. While gathering data to find the most suitable single men available, she wades through a series of unsavory, stale dates, which literally places her back at ground zero. Just when she is ready to give up, sin personified in the form of sexy firefighter Jett Avery, arrives tainting all of her previous data.

A traumatic warehouse fire, in which firefighter Jett Avery's closest friend dies, has him suffering from Posttraumtic Stress Disorder. Attempting to stave off the worst of his depression, he decides to use his brand of therapy...Sex. The remedy has lost luster until he encounters ER nurse Roxanne Carter.

Heart Surgeon Stone Lassiter has successfully transplanted beating hearts. It's his own that is causing him the most agony. With a death bed promise to his fiancée, he’s driven to open a transplant center in her hometown, and arrives at Deerborne County General Hospital. Single minded in his focus, he inadvertently alienates the nursing staff he needs to make his dream a success. He sets his stethoscope on intensive care nurse, Faith Daniels, to improve his image.

Nurse of the Year, Faith Daniels has passed every nursing exam, but when faced with the task of the MCAT, she has severe test anxiety. Burned by her ex-husband, who used her while she put him through law school, she has become focused on passing that darn exam, and achieving her own dream to become a doctor in her own right.

Will the white lie Stone tells Faith jeopardize the love they find?